Buprenorphine Update: Bupe is (still) “Butiful”

Author: Alec Feuerbach  Peer Reviewers: Trevor Cerbini, Nicole Anthony Faculty Reviewer: Scott Kendall   Two years ago, Dr. Trevor Cerbini wrote an excellent post for this blog highlighting the basics – and beauty – of buprenorphine (bupe). He highlighted the staggering mortality of Opioid Use Disorder (OUD), explaining that 5.5% Read more…

Cellulitis – Observe, Admit, or Discharge?

Cellulitis is commonly diagnosed and treated in the Emergency Department ED) with considerable variation in treatment and disposition patterns. These patients may be: Given a dose of intravenous (IV) antibiotics before discharge home Placed in observation unit for IV antibiotics before transitioning to oral medications prior to discharge Discharged with Read more…

Morning Report: 9/21/2012

Thanks Dr. Coquillon for today’s Morning Report!   Alteplase: Mechanism of Action Recombinant human tissue-type plasminogen activator (t-PA); produces local fibrinolysis Promotes thrombolysis by converting plasminogen to plasmin which degrades fibrin and fibrinogen Pharmacokinetics Initial Half-Life: 5 minutes (free unbound form) Terminal Half-life: 72 minutes Onset: Coronary thrombolysis occurs in Read more…