Toxic shock-like syndrome and COVID-19: A case report of multisystem inflammatory syndrome in children (MIS-C)

This article is reposted from The American Journal of Emergency Medicine.  Introduction The coronavirus disease 2019 (COVID-19) pandemic has caused a total of nearly 300,000 deaths worldwide [1]. Pediatric patients PCR-postive for SARS-CoV-2 present differently than adults with 40% either asymptomatic or with URI symptoms and commonly have pharyngeal erythema Read more…

Multi-Organ Failure from Cellulitis – Streptococcal Toxic Shock Syndrome (STSS)

A 54-year-old male with history of alcohol abuse presents with right forearm pain and swelling following a fall two days ago. The pain is constant, sharp, “radio buzzing”, and 10/10. He also reports redness, swelling, and “feels cold”. He denies fevers, LOC, CP, SOB, weakness/numbness. Initial VS: HR 120/min, RR 20/min, Read more…

Xigris: The drug that cured sepsis… but then actually didn’t

In 2001, the only drug to treat sepsis was approved by the FDA and swiftly brought to market by Eli Lilly & Co. So, why have most residents never heard of Xigris (drotrecogin alfa)?                                                                                                                                                                                                             By Dr. Lee Grodin   [1] Bloomberg News. Lilly Read more…

Fever…Huh

What is it good for?   Something?  Maybe?  Remember in medical school when the right answer to everything was cytokines.  The mythical inflammatory response; all those interleukins, TNFs, and all other forms of molecular magic that drive our response to infection.  The so-called “pyrogens,” or molecular agents causing fever, are Read more…