Case:

It’s your 5th straight night and your pediatric ED shift ends in one hour. A few stable patients came in during your shift, and you’re happy about that. No one wants kids to be sick. Your mind begins to wander. To be honest, the inner fat kid you’ve always been is really just craving pancakes at this point after you leave work.

An attending comes to visit from Adult ED and asks “Breakfast?!”  followed by “How was your night?” You say the Q word, “quiet”, because you’re not superstitious like that. You hear lightning strike outside as everyone’s mouth drops open, nearby staff turn to glare at you, a flock of birds begins to head to a different city, and the EMS notification phone rings twice in a row. Way to go.

A 14-year-old boy is brought into the ED by EMS with altered mental status. He has no past medical history. Dad says the patient has not been feeling well over the last few days and he has been having fevers as well as cough with green sputum. This morning he was difficult to arouse for school and Dad called 911.

The heart rate is 130 with a respiratory rate of 33 and a pressure of 98/62. The patient is responsive to verbal stimuli, there is a fruity odor on his breath, and he has dry mucous membranes. He has rapid, deep breathing, tachycardia, and the bedside fingerstick glucose reads: HIGH

The basic metabolic panel results appear on your monitor: Na 129 mmol/L, K 4.0 mmol/L, Cl 96, HCO3 7, BUN 39, Cr 1.1, and glucose 600. He has positive ketones in his urine and serum beta-hydroxybutyrate is twice normal limits.

 

What is the pathophysiology?

 

Why do diabetics get DKA?

 

What are the clinical features?

 

How is it diagnosed?

 

You diagnose the patient with DKA. The nurse is proactive and asks if you would like to start insulin. You remember potassium cannot be too low before starting insulin but is it high enough? Do they need K repletion?

 

How is DKA treated?

 

This is primarily a board review post and is not meant to be an up to date literature review.

 

References

  1. Kefer MP. Diabetic ketoacidosis. In: Tintinalli JE, Cline DM. Tintinallis emergency medicine manual. 7th ed. New York: McGraw-Hill Medical; 2012: 628-630
  2. Vella A. The diabetic child. In: Tintinalli JE, Cline DM. Tintinallis emergency medicine manual. 7th ed. New York: McGraw-Hill Medical; 2012: 380
  3. Shafi O, Kumar V. Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution. Pediatric Endocrinology Diabetes and Metabolism 2018;24(2):56–64.
  4. Kuppermann N, Ghetti S, Schunk JE, et al. Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis. New England Journal of Medicine 2018;378(24):2275–87.
  5. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic Crises in Adult Patients With Diabetes. Diabetes Care 2009;32(7):1335–43.

 

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1 Comment

Dr. Paul Pukurdpol · October 17, 2018 at 2:51 am

Excellent review of DKA and potassium management Dr. Aurrecoechea! I noticed that you cited a common adult DKA management algorithm in your discussion. Your case, however, was a 14 year old, and there are some important differences in the management of adult vs pediatric DKA. The most important difference is that, while bolus dosing of insulin is a common practice in adult DKA (often due to Type II DM), bolus dosing of insulin has been found to be harmful in children, as they are often exquisitely sensitive to insulin and are at greater risk of hypoglycemia.

In addition to being gentle with insulin, we should also be more gentle with fluid resuscitation, in order to prevent cerebral edema. A June 2018 NEJM article by Kuppermann et al from the PECARN group found that it was safe to give a “rapid” infusion of NS or 1/2 NS, however “rapid” was defined as two 10 cc/kg boluses in the first hour. That is to say ONE standard 20 cc/kg bolus of NS, followed by twice maintenance, constitutes “rapid” fluid resuscitation in pediatric DKA – way less than we are used to giving in adults. Notably, you could also go “slow” and just give one 10 cc/kg bolus, and outcomes were essentially unchanged, which is the route CHOP chose for their DKA protocol (see https://www.chop.edu/clinical-pathway/diabetes-type1-with-dka-clinical-pathway). Children just don’t seem to get as hypovolemic as adults do.

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